The National Trust of Historic Places just released a list of a Dozen Distinctive Destinations, which includes Florida's Apalachicola. The City of Apalachicola is known for its oysters, but there is more to the story than just shellfish.
To learn more, I recommend:
Florida's Forgotten Coast: Life on the Apalachicola Bay, an Oral History project from the Southern Foodways Alliance
Apalachicola River--An American Treasure, by Clyde Butcher (University Press of Florida, 2006)
Voices of the Apalachicola, Edited by Faith Eidse (University Press of Florida, 2007)